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Swiss Apple

Swiss Apple

60 Capsules
Product Code: SA1181
Retail Price: $39.99 Online Price: $28.50

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The secret of Michelle Obama's youthful looks may be a rare Swiss apple with an exceptionally long shelf-life.

According to the US edition of Vogue, the First Lady buys a £215 serum which uses an extract from the stem cells of the Uttwiler Spätlauber apple.

The variety stays fresh for up to four months after being harvested, long after other varieties have become wrinkled.

Stem cells from the fruit are said to stimulate human skin stem cells, thereby protecting skin cell regeneration and delaying the onset of wrinkles.

It is being hailed in the cosmetic world as an exciting anti-ageing breakthrough and has been snapped up by around 100 beauty firms in Europe, Asia, and the United States, including Lancôme and Chantecaille. 

Vogue has dubbed it "the super apple" and asked if the tree could be "the new fountain of youth".

Despite its long shelf-life, the apple has not been considered desirable until now because of its tart taste. Consequently the number of trees has rapidly dwindled.

The variety, first recorded in the mid-18th century, comes from northern Switzerland. If the tree's bark or the skin of an unpicked fruit is punctured it heals. And once picked, an Uttwiler Spätlauber apple lasts months longer than its shrivelled cousins.

Swiss scientists at Mibelle Biochemistry, which is a subsidiary of the big Swiss retailer Migros, decided to investigate whether the miracle component could be harnessed to stop the ageing process in people.

They found the key to the apple's longevity lay chiefly in its unusually resilient stem cells.

In clinical tests the apple's stem cells appeared to be protecting human stem cells. They nourished and stimulated them and defended them against UV radiation.

They made a cream containing a two per cent Uttwiler Spätlauber extract and applied it twice daily to the "crow's feet" area under the eyes of 20 participants. Wrinkle depth was reduced by an average of 15 per cent after four weeks.

"We thought there must be something in those apples which gives them their long shelf life," said Beata Hurst, marketing and sales manager at Mibelle Biochemistry.

"We could show that the apple stem cells have a positive influence on the vitality of the skin stem cells. They made them more efficient and they can live longer."

At present there are only 20 Uttwiller Spätlauber trees in Switzerland. They belong to ProSpecieRara, a foundation aiming to preserve traditional breeds of animals and plants in Switzerland.

The organisation has managed to preserve 1,800 varieties on 8,000 trees during its 25 years in operation, through collecting samples, growing them and then distributing them to people willing to look after them.


All Natural Way for a Younger Looking

Swiss AppleTM, an organic formula, is a novel solution to protect and preserve the youthful look and vitality of your skin. A plant cell culture technology has been invented to cultivate dedifferentiated callus cells from a rare Swiss apple. These apple stem cells are rich in epigenetic factors and metabolites, assuring the longevity of skin cells.

Collagen, the main structure element of the skin, provides excellent smoothing and hydrating qualities with superb skin feel.
Antioxidants and Vitamin E help correct specific areas of concern, such as the appearance of darkness and puffiness under the eyes, fine lines, rough skin, loose skin.
Matrixyl 3000® helps increase cell turnover, firmness, elasticity and smoothness and brings about fine line reduction.




Supplement Facts
Serving Size: 4 Capsules
Per serving contains: 15
  Amount Per Serving % Daily Value
   Swiss Apple
(Uttwiler Spatlauber) (Stem)
1,200 mg **
  Proprietary Blend
Antioxidants (Berry Extract), 
    Fish Collagen®
   Soy Bean (95% Dehydroepiandrosteone),
    Vitamin E

800 mg


*Percent Daily Values are based on a 2,000 calorie diet.
**Daily value not established.

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Take 2 capsules twice a day with water before meal time.

Swiss Apple(Uttwiler Spatlauber)


What About Uttwiler Spatlauber?

The Uttwiler Spätlauber, which was first recorded in the 18th century, comes from canton Thurgau, in northern Switzerland.
It is well known for its excellent storability; it can stay fresh looking for up to four months after being harvested, long after other varieties have become wrinkled.

Amazing longevity

Having collected some samples, Swiss researchers set to work and found that the answer mostly lay in the amazing longevity of the apple's stem cells.

Humans have skin stem cells, which replenish and maintain the balance of cells within the skin tissue and regenerate tissue which has been damaged.

But with age, the number of skin stem cells decreases and their ability to repair the skin becomes less efficient. The result is – with added environmental damage like UV rays - a loss of skin vitality, and inevitably, wrinkles.

Mibelle Biochemistry, which developed the apple ingredient, found that the apple stem cells were protecting the skin stem cells from ageing.


Could the extract from a rare Swiss apple REALLY get rid of your wrinkles?

Surprisingly, it all started with an apple. A dull, sour apple, almost extinct, living quietly on a rare tree in a remote part of Switzerland.

Now, that humble apple is a big celebrity, with fans such as Michelle Obama, Helen Mirren and Jennifer Lopez.

It spends its time among beautiful people in swanky department stores. Why? Because this Swiss fruit is at the centre of what's being described as a 'revolution' in anti-ageing treatments.

It's claimed this ingredient can reverse skin ageing, increase the lifespan of human cells, and may even make it possible to grow back lost hair.                                                          

I'm used to hyperbole in the beauty world, but this new development is really getting the cosmetics companies excited.

They believe they have the science to prove that plant stem cells can be incorporated in skin creams, will interact with human skin stem cells, and can eliminate wrinkles and make skin look younger.

Human stem cells can turn into any part of the body and so are big news in medical research, but the law bans the use of embryonic stem cells in cosmetics.

So, instead, researchers turned their attention to plants. These also produce stem cells throughout their lives, both to grow, as a response to an injury.

The biggest 'star' in the stem cell world is called PhytoCellTec Malus Domestica.

Derived from a rare 18th-century species of apple tree, the Uttwiler Spatlauber, it first attracted attention, as it could be kept for months without withering.

In a paper published in the cosmetics industry journal, the Journal Of Applied Sciences, Swiss scientists noted: 'These apples must have especially long-living tissue stem cells. Could we profit from these stem cells?

'What would be the effect of an extract of such long-living stem cells on the skin?'

To find out, scientists cut pieces of the apple, which responded by forming a protective 'callous' made of plant stem cells on the surface.

These cells were grown in a liquid culture and put to the test. A solution containing one per cent apple stem cells seemed to boost cell production of human stem cells by a staggering 80per cent.

The human cells were irradiated with UV light, which killed 50 per cent of those grown in a normal liquid culture, but hardly any of those protected by the apple stem cells.

Also, hair follicles kept in a solution of Uttwiler Spatlauber continued to grow for 18 days, while those kept in a typical solution died after 14.

And, in tests on 20 women, applying a cream enriched with 2 per cent PhytoCell-Tec Malus Domestica twice a day reduced crows feet by eight per cent after a fortnight, and 15 per cent after four weeks.

Skincare companies rushed to include it in their ranges. But it doesn't come cheap. 3Lab, from Urban Retreat in Harrods and Selfridges, offers its Super 'h' Serum, £215, and M cream, £185.

Both contain apple stem cells, as does the company's £70 skin firming and lifting Super C Serum. Lancome has Absolue Precious Cells, £145 for 50ml, an anti-ageing cream it claims will 'help restore the potential of skin stem cells and bring back the skin of youth'

Emerge Swiss Apple Stem Cell Serum (available online for £72), allegedly 'promotes the selfrenewal capacity of the skin' and in the U.S., youth-hungry celebs such as Gwyneth Paltrow and Julianne Moore all feted the launch of Cellular Lifting Serum from Clark's Botanicals, is £355 for just 30ml.

But, Professor Liam Dolan, the Sheradian Professor of Botany at Oxford University, who specialises in studying plant cells, is sceptical about the new ingredient. 'I don't see how plant stem cells could interact with human stem cells in this way,' he says.

But Dr Daniel Schmid, research director of Mibelle Biochemistry, the Swiss lab which developed PhytoCellTec Malus Domestica, insists that his study shows his apple stem cell extracts have been 'shown to improve the maintenance of the stem cells characteristics of epidermal stem cells.'

He admits: 'The anti-ageing benefit for the skin after topical application could not be confirmed in a clinical trial.'

But, he adds: 'The extract offers a promise of real skin rejuvenation.'

Further studies would be needed to prove that plant stem cells truly are as effective on faces as they are in the lab, but in our search for the elixir of youth, a new cream that can peel away the years, dreams tend to win over doubts, and this little apple looks as if it's going to bask in the limelight a little longer yet.



According to the Bible, Adam bit into an apple (coaxed on by us femme fatales) and deprived Earth of Heaven...was he attracted by the delicious taste or did he already know of the amazing youth-boosting properties of this fruit?

PhytoCellTec Malus Domestica is an award-winning patented liposomal preparation, so containing tiny bubbles made out of the same material as cell membranes, based on the stem cells of a rare Swiss apple called Uttwiler Spätlauber that derives from a seedling planted in the middle of the18th century. Uttwiler Spätlauber is an endangered apple variety that is well-known for its ability to be stored for long periods without shrivelling and thus its longevity potential. The apples are rich in phytonutrients, proteins and long-living cells. A novel technology has now been developed enabling the cultivation of rare and endangered species like Uttwiler Spätlauber. Thanks to this technology, plant stem cells can be obtained and incorporated into skin care products to enhance the longevity of skin cells. Not only does it protect the skin’s own stem cells but has been shown to have excellent age-delaying and anti-wrinkle properties, and is currently one of the most pioneering and exciting ingredients in skin care.

Stem Cells and Longevity

Longevity is related to specific cells called stem cells which have a unique growth characteristic. These cells can make identical copies of themselves as well as differentiate (in other words, split) to become separate, specialised cells. Two basic types of stem cells are present in the human body:

Embryonic stem cells found in blastocysts (structures found in the human pre-embryonic stage) can grow and differentiate into one of the more than 220 different cell types which make up the human body;

Adult stem cells located in some adult tissues can only differentiate into their own or related cell types. These cells act as a repair system for the body but also maintain the normal turnover of regenerative organs such as blood, skin or intestinal tissues.

Research on Stem Cells and Applications

Currently in medicine, adult stem cells are already used particularly in transplant medicine to treat leukemia and severe burns. In the cosmetic field, scientists are focusing their research on adult stem cells located in the skin. They are studying the potential of this type of cells, their functioning and aging. This research is helping us understand how to protect skin stem cells.

Stem Cells in the Human Skin

In the human skin, two types of adult stem cells have been identified:

  • Epithelial skin stem cells which are located in the basal layer of the epidermis.
  • Hair bulge stem cells located in the hair follicle.

Epidermal or skin stem cells replenish and maintain the balance of cells within the skin tissue and regenerate tissue damages during injury. But with age, the number of skin stem cells decreases and their ability to repair the skin becomes less efficient.

Plant Stem Cells to Protect Skin Stem Cells

In contrast to human, plant cells are totipotent, meaning that every cell has the ability to regenerate new organs (leaves, flower, seed…) or even the whole plant. Besides, all plant cells can differentiate and become a stem cell. All stem cells, independently of their origin (plant, animal or human) contain specific epigenetic factors whose function is to maintain the self-renewal capacity of stem cells.




The anti-wrinkle effect of Malus Domestica was evaluated in a study with 20 volunteers aged from 37 to 64. An emulsion containing 2 % of PhytoCellTec™ Malus Domestica was applied twice daily for 28 days to the crow’s feet. Wrinkle depth was determined by means of PRIMOS (phase-shifting rapid in vivo measurement of skin). Results showed a significant and visible decrease in wrinkle depth for 100 % of the subjects.


Hair follicles are mini organs that represent a natural combination of epidermal and melanocyte (cells in the bottom layer of the skin) stem cells. The follicles can be maintained in a growth medium where they elongate until about day 14. Then the follicle cells gradually become senescent or undergo apoptosis – effectively they deteriorate and start to die - which is caused by the lack of blood circulation. Isolated hair follicles represent a good test model to analyse actives ingredients, such as Malus Domestica, that can delay the cell deterioration and death process. Isolated human hair follicles were incubated with Malus Domestica extract. Addition of 0.2 % of this extract was found to slightly but clearly postpone deterioration and necrosis: follicles kept in presence of the Malus Domestica stem cell extract continued to elongate until day 18, whereas the control follicles started to shrink after day 14.


Change in hair follicle length compared to Day 14 in %




An in vitro test was conducted on blood stem cells with Malus Domestica stem cell extract. The influence of Malus Domestica stem cell extract on blood stem cell growth was evaluated by counting the cell number after incubation. Results showed that Malus Domestica stem cell extract has a positive effect on stem cell growth thus maintaining the growth and the proliferative activity of stem cells.


Increase in Cell Growth Activity




Another test was conducted on blood stem cells. The protective effect against UV damage of Malus Domestica stem cell extract was evaluated by scientific analysis. Cells were incubated with different concentrations of Malus Domestica stem cell extract for 24h and were then exposed to UV radiation. The analysis, which measures the number of cells still living and therefore the damage from UV, was performed 48 hours after UV radiation. Results showed the capacity of Malus Domestica to protect cells from UV damage even at low concentrations.


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